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GLP-1 receptor agonists versus metformin in PCOS: a systematic review and meta-analysis

and the simultaneous receptor engagement, that had been seen in monkeys, of GIP, glucagon, and GLP-1 was confirmed in humans

The GLP-1 hormone also slows digestion, inhibits the release of glucagon (another hormone that regulates blood glucose), and helps signal to your brain when youve had enough to eat

Since this is so rare a complication, in so few patients, it is difficult to delineate the exact mechanism

Glapp deserves credit for medication-cycle interpretation, supply tracking, outside benchmarks, and research-style answers

The risk of weight regain needs to be addressed, perhaps through individualized dose-tapering strategies, given the increasing popularity of these agents for weight loss and the high discontinuation rates