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Include healthy fats : Incorporating moderate amounts of unsaturated fats from sources like olive oil, avocados, nuts, and fatty fish may support GLP-1 secretion, though evidence specifically comparing fat types is still emerging

Support with Lifestyle: Use the appetite suppression window to build better habits

Over the years, researchers have followed this drug to see who it harms in certain organ systems and haven't seen any significant red flags in the heart or blood vessels [7]

Several landmark cardiovascular outcome trials have demonstrated that GLP-1RAs can significantly reduce the risk of major adverse cardiovascular events (MACE), which include cardiovascular death, nonfatal myocardial infarction (heart attack), and nonfatal stroke [43]

( Figure 5 ) Briefly, SGLT2i inhibits the SGLT receptors in the proximal tubule, which inhibits the reabsorption of glucose from primary urine, resulting in glycosuria and a decrease in HbA1c and fasting glucose levels ( Figure 5 Clinical implications Given the significant cardioprotective effect of SGLT2i and GLP-1RAs, the ADA guidelines state that all diabetic patients with confirmed or subclinical cardiovascular disease should be prescribed a GLP-1RA class or SGLT2i class with proven cardiovascular benefit, regardless of the patients HbA1c level or the presence of other glucose-lowering medications ( Strengths and limitations To the best of our knowledge, this is the first meta-analysis to assess the effects of SGLT2i and GLP-1RAs as first-line therapeutic agents in T2DM patients with low cardiovascular disease risk

This opens an opportunity for oral small-molecule therapies that target the well-validated GLP-1R for metabolic health