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Mechanisms of Insulin Resistance, Mitochondrial Dysfunction and the Action of the Ketogenic Diet in Bipolar Disorder

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Notably, the extracellular perineuronal net surrounding ARC neurons undergoes remodeling in metabolic dysfunction [58]

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That is standard practice

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This taste distortion can further reduce the desire to eat, creating a downward spiral of reduced intake, worse dehydration, and worse dry mouth

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