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A 2025 study published in JAMA Network Open found that most patients with obesity discontinue GLP-1 therapy within a year, particularly those without type 2 diabetes 1

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Keywords: Appetite and eating behaviors, Exit interviews, Obesity, Obesity management medication, Retatrutide Graphical abstract 1

GLP-1 slows gastric emptying, keeping dairy longer in the stomach and impairing lactose digestion