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Description
Impact of intensive lifestyle and metformin therapy on cardiovascular disease risk factors in the diabetes prevention program

Physical activity research for weight maintenance often shows requirements that exceed general health guidelines

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There was no significant change in BMI in the control group at any time point

Effects of the insulin sensitizer metformin in Alzheimer disease: pilot data from a randomized placebo-controlled crossover study

does not require metabolic activation Clinical uses Prevention of chemotherapy-induced nausea and vomiting (CINV) Prevention of postoperative nausea and vomiting (PONV) Prevention of radiation-induced nausea Pharmacokinetics Oral, IV, or sublingual administration Rapid absorption (oral bioavailability ~60%) Metabolized by CYP3A4, CYP2D6, CYP1A2 Excreted in urine and feces Not a prodrug Adverse effects Headache Constipation Dizziness Rare: QT prolongation (dose-dependent) Ondansetron = Active drug Metoclopramide = Active drug Domperidone = Active drug Prodrug examples in GI system: none commonly
