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There's also a larger question hanging over the Medicare breakthrough: Unless the Trump administration extends or replaces the demonstration program, obesity drug coverage is scheduled to expire at the end of 2027

In the meantime, the evidence supports GLP-1RAs as a strong alternative to metformin, especially in cases where weight loss is a primary treatment goal

In the case of obese individuals, an elevated BMI has been linked to increased interactional displacement, primarily stemming from the continuous movement of the skin and subcutaneous adiposity [31]

Nature 418 , 650654 (2002)

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However, in June we observed a shift: among patients with an active supply of AOM tirzepatide, 90.4% had an active supply of the AOM tirzepatide in July, while 8.0% switched to AOM semaglutide