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Description
So far, three major problems have kept GLP-1 drugs injectable rather than oral: enzymatic degradation, poor bioavailability, and the sheer cost of manufacturing
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Methods A comprehensive search identified relevant randomized controlled trials comparing combination therapy with SGLT-2i and GLP-1RA to monotherapy or treatment as usual (TAU)
The literature search was independently performed by three investigators
Nevertheless, the P5-induced increase in [Ca 2+ ] i in CHO-GLP-1R expressing cells was inhibited by the selective Gq inhibitor FR900359 (refs 17, 18
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