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Gerstein HC, Colhoun HM, Dagenais GR, et al

Discuss this approach with your prescriber before implementing, as it represents off label modification of standard protocols

This uniformity makes the tirzepatide escalation more predictable than semaglutide, where the jumps are uneven (0.25, then 0.5, then 0.7, then 0.7 again)

They reduce insulin resistance

[22] [23] Baseline assessment should be considered before initiating tirzepatide in high-risk patients, including those over 65 years of age, individuals with pre-existing gastrointestinal disorders, patients on concurrent metformin or acid-suppressing medications, and those following restrictive diets

States including Idaho and Tennessee have announced investigations into illegal dispensing by medical spas and other providers, while states such as California are looking to beef up their oversight