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GLP-1 receptor agonist drugs (e.g., semaglutide, liraglutide, tirzapeptide) work by mimicking natural GLP-1 but last much longer

All these pathways eventually lead to an increase in the intracellular Ca 2+ concentration, thereby promoting the mitochondrial synthesis of ATP, and the release of insulin particles into the blood through exocytosis

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Both agents rapidly alleviate symptoms through the downregulation of key inflammatory mediators, including TNF-, IL-6, and IL-17, leading to a reduction in erythaematous, scaling, and pruritic manifestations, along with the suppression of pathological keratinocyte proliferation and immune infiltration 12,13
All methods were carried out in accordance with relevant guidelines and regulations