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GI side effects usually stabilize during this phase
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Acid reflux and GERD risk This is the biggest concern with nighttime tirzepatide injections, and most timing guides barely mention it
Renal problems : Rare cases of kidney injury due to dehydration from vomiting or diarrhea
Airplane cabins are typically pressurized and climate-controlled, but once you land or spend time in higher temperatures, active cooling becomes necessary to prevent medication degradation
Storage considerations during the transition also matter
