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The convenience factor diminishes when efficacy becomes unreliable

For example, the glutathione disulfide (GSSG) reduction to glutathione (GSH) is driven by the NADPH generated during the first step of the PPP pathway, when glucose-6-phosphate is converted to 6-P-gluconate

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A patient who lost weight but developed fatigue, constipation, under-eating, or muscle weakness may need a different strategy than a patient who lost weight steadily, maintained strength, and improved lab markers

Tirzepatide and semaglutide are not identical in side effect profile, despite sharing the GLP-1 receptor pathway

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