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Semaglutide and cardiovascular outcomes in patients with overweight or obesity

The metabolic action of GLP-1GIPlanifibranor is blunted in mice with genetic or pharmacological inhibition of GLP-1R, GIPR or PPAR and is absent in DIO double incretin receptor-knockout mice, collectively suggesting that GLP-1GIPlanifibranor has substantial therapeutic value in the treatment of obesity and diabetes

Moreover, the complex pathogenesis of PD makes it a suitable target for GLP-1RAs, which modulate numerous intracellular signaling pathways, as demonstrated by in vitro and in vivo studies

"The media is really kind of spun this like pharma companies are making a lot of money and people using this drug when it's not prescribed properly, etcetera, and people are losing weight like it's a bad thing

10.1016/j.bbrc.2015.08.092 238