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Other studies have claimed that peripheral GLP-1 might bind to GLP-1R on the vagal afferent neurons, mainly located in portal circulation, and generate electrical signals to the brain, as was demonstrated in vagotomized rodent models in which GLP-1 did not reduce feeding [58,79,80]
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8.1 Pregnancy Risk Summary Based on animal reproduction studies, there may be risks to the fetus from exposure to liraglutide injection during pregnancy
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Exendin-4 protects against hyperglycemia-induced cardiomyocyte pyroptosis via the AMPK-TXNIP pathway
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