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Some of the dual and triple agonists have already shown initial successes in clinical trials, although the molecular mechanisms underlying their multiplexed pharmacology remain elusive

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Meanwhile, PA decreased the levels of GLUT4 and phosphorylation of Akt and affected SESN2 expression

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GLP-1 receptor agonists like semaglutide may be appropriate after bariatric surgery, but timing, anatomy, and individual health factors determine eligibility and dosing strategy

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