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doi: 10.1159/000381643 157 GongLGoswamiSGiacominiKMAltmanRBKleinTE

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The dosing schedule then continues with incremental increases of 2.5 mg after at least four weeks at each dose level, progressing through the following sequence: 2.5 mg once weekly (weeks 1-4): Initial tolerability dose only 5 mg once weekly (weeks 5-8): Minimum therapeutic dose 7.5 mg once weekly (weeks 9-12): Intermediate dose option 10 mg once weekly (weeks 13-16): Higher therapeutic dose 12.5 mg once weekly (weeks 17-20): Higher therapeutic dose 15 mg once weekly (week 21 onward): Maximum approved dose The FDA label specifies that dose escalation should occur after at least four weeks at each dose level, though clinical judgment may warrant extending this timeline if patients experience significant gastrointestinal symptoms

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[7] [8] Readers should check the current NICE Technology Appraisal for tirzepatide in weight management and the emc SmPC (medicines.org.uk) for the most up-to-date information on its licensed indications and eligibility criteria in the UK, as guidance may be updated