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Over the last decade, several studies have investigated the role of glucose-lowering drugs in cardiovascular outcomes, especially glucagon-like peptide-1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) which have demonstrated substantial improvements in major cardiovascular events, kidney function outcomes, and hospitalizations [3]

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The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors

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doi:10.2174/1381612825666190206105232 13