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While that study did not focus on lactation transfer specifically, the overall lack of lactation-specific evidence is one reason many clinicians recommend postponing restart until breastfeeding or pumping ends

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Androgenic Modulation of the Chloride Transporter NKCC1 Contributes to Age-dependent Isoflurane Neurotoxicity in Male Rats

Pharmacogenetic studies and meta-analyses support the role of polymorphisms in the SLC6A4 promoter region (5-HTTLPR) and related methylation patterns in moderating antidepressant response and risk of adverse effects, although effect sizes are modest and findings vary by ancestry and study design [25,26]

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This adaptation may persist for varying periods after weight loss, potentially contributing to ongoing cold sensitivity