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Some people may notice changes sooner, while others need more time to see full benefits

Reactive oxygen species in vascular wall

Patients with a history of hypersensitivity reaction to other GLP-1 receptor agonist should not be started on semaglutide

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Average Weight Loss in the Orforglipron phase 3 ATTAIN-1 Trial Across the 72-week study period, participants: Lost up to 15% of their body weight at the highest dose At 36 mg: 54.6% lost 10%, 36.0% lost 15%, 18.4% lost 20% body weight (all higher than placebo)

Treatments for diabetes must also be easy to implement into daily life due to the long-term nature of the disease [197]