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In addition, some aspects of GLP-1 beyond weight loss, such as preclinical evidence on GLP-1 effects in directly modulating the hypothalamuspituitarygonadal axis, or the effects of GLP-1RA on clinical and biochemical expression of hyperandrogenism, still deserve a greater insight, especially in light of a possible therapeutic use in PCOS women independently of obesity

Impacts Gut Microbiota Some research indicates that GLP-1 drugs can alter the balance of gut bacteria, which may contribute to metabolic benefits but could also affect digestion

Observational studies in autoimmune rheumatic diseases (ARDs) such as rheumatoid arthritis and systemic lupus erythematosus indicate

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