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Contact your healthcare provider promptly if you experience: Persistent dizziness lasting more than a few seconds when standing Fainting or near-fainting episodes Falls or loss of balance attributed to dizziness Chest pain, palpitations, or irregular heartbeat accompanying low blood pressure symptoms Severe or persistent nausea, vomiting, or diarrhea leading to dehydration Confusion, difficulty concentrating, or unusual fatigue Blood pressure readings consistently below 90/60 mmHg with symptoms New or worsening shortness of breath Seek emergency care (call 911) if you experience: Loss of consciousness Chest pain or pressure Severe shortness of breath Confusion or altered mental status Seizures Signs of stroke (facial drooping, arm weakness, speech difficulty) Your healthcare provider may need to adjust your GLP-1 medication dose, modify or discontinue antihypertensive medications, or investigate other potential causes of hypotension

If the next step is labs, blood pressure review, abdominal symptoms, dehydration risk, an exam, or a medication adjustment, you are not stranded with a chat box

Abstract Purpose of Review To discuss evidence supporting the use of glucagon-like peptide 1 receptor agonists (GLP-1RA) to treat obesity and their role as a cardioprotective drug

10.1002/jor.24388

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Larger peptides with post-translational modifications (like the fatty diacid moiety on retatrutide) are more susceptible to degradation than simpler sequences