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In addition, previous studies have shown that administration of Exendin-4 may increase patients anxiety, which may exacerbate the anxiety of heroin withdrawal patients after medication, making it difficult for them to tolerate this anxiety and give up continuing medication or develop into depression, which may limit the development of GLP-1 analogs [27]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 184.Gutzwiller J.P., Gke B., Drewe J., Hildebrand P., Ketterer S., Handschin D., Winterhalder R., Conen D., Beglinger C