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Mechanistic Comparison# Dosing Comparison# CT-388 Dosing# CT-388 is administered as a once-weekly subcutaneous injection

(Clearing the System) Because tirzepatide and semaglutide both have long half-lives (5 or 7 days, respectively), healthcare providers may recommend a short washout period before starting the new medication

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This excess estradiol then suppresses gonadotropin-releasing hormone (GnRH) in the hypothalamus, which reduces LH and FSH output from the pituitary, which further reduces testosterone production from the testes

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