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Additionally, evidence-based strategies help prevent weight regain, ensuring patients maintain results and continue progressing toward improved metabolic health

That means: This approach wont appeal to every patient

Neither the levels of blood glucose nor prior metformin treatment were associated with the changes in incretin hormones or rates of gluconeogenesis

Mace et al
Exendin-4 protects the hearts of rats from ischaemia/reperfusion injury by boosting antioxidant levels and inhibition of JNK/p(66) Shc/NADPH axis

They require chemical modifications and injections to remain effective
