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Chronic stress elevates cortisol, which promotes visceral fat storage, breaks down muscle tissue, increases appetite for high-calorie foods, and impairs insulin sensitivity

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Jun LS, Millican RL, Hawkins ED, et al

GLP-1R V229A substitution affects receptor trafficking, activation and signalling in pancreatic beta cells To determine the effects of the GLP-1R V229A substitution on GLP-1R trafficking, we assessed GLP-1R internalisation, recycling and degradation parameters in INS-1 832/3 SNAP/FLAG-hGLP-1R WT versus V229A cells
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"I was almost numb to it," she said
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