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Quick Summary: Heart rate elevation is a documented side effect of retatrutide observed in clinical trials

Frequently asked questions Does tirzepatide interact directly with alcohol

If the stinging is severe or persists for hours, the medication may have degraded, the pH may be off, or you may have a sensitivity

Clinicians must also remain vigilant for rare but serious complications, such as bowel obstruction, particularly in patients with preexisting motility disorders, although these risks may be overstated when comorbidities are considered (Jones and Cappola, 2025

Avoid or limit NSAIDs (like ibuprofen) which can irritate the stomach
