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injections.49,55 After an initial positive response to short-acting somatostatin analogues lasting from several weeks to months, patients can be converted to long-acting somatostatin analogues providing equal symptomatic benefit.5,9 Patients prefer long-acting formulations primarily because of the lower number of injections required: once every four weeks intramuscular instead of 13 times s.c

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Rats receiving vagotomy do not reduce food intake in response to peripherally injected GLP-1 indicating that vagal afferent nerves are needed to relay peripheral GLP-1 signals to higher brain regions to regulate feeding (Abbott et al., 2011)

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After taking into account any exclusions, the researchers identified three cohorts: GLP-1 use vs