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GLP-1 medications like Ozempic (semaglutide) and Mounjaro (tirzepatide) mimic this hormone to help reduce hunger, increase fullness, and slow digestionall of which can support healthy weight loss

Doctors may prescribe it off-label to treat obesity

[DOI] [PubMed] [Google Scholar] 88.Abbott CR, Monteiro M, Small CJ, Sajedi A, Smith KL, Parkinson JRC, et al

The existing evidence is promising, but retatrutide should not be presented as an available clinical therapy until approved by regulatory agencies

In addition, co-treatment of obese mice with GLP-1RA and an NMDA receptor antagonist can induce greater change compared to GLP-1RA alone [51]

In a 12-month, two-phase trial, subcutaneously administered lixisenatide moderately reduced the progression of motor dysfunction in patients with early Parkinsons disease (PD) compared to placebo (Meissner et al., 2024)