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Over time, however, your brain and digestive system become accustomed to the medication's effects, a process called tachyphylaxis

You may also have some discomfort at the vein access site on your arm

Did I rotate injection sites

In patients with varying degrees of renal or hepatic impairment, no relevant change in dulaglutide exposure was observed relative to the degree of renal or hepatic impairment (132)

37 They found that only [Aib 8 ]- and [Gly 8 ]-GLP-1(736)-NH 2 exhibited comparable receptor binding to GLP-1 (IC 50 of 0.45 and 2.8 nM, respectively, compared to 0.78 nM of GLP-1)

Additionally, many patients abandon GLP-1 medications due to intolerable side effects, including nausea, vomiting, diarrhea, and fatigue