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Compounded tirzepatide is prepared by a state-licensed compounding pharmacy under physician supervision
In a post hoc analysis of the SUMMIT trial, the decrease in estimated blood volume seen in participants treated with tirzepatide was significantly correlated with decreased blood pressure, lower microalbuminuria, improved KCCQ-CSS, and greater 6-min walking distance [85]
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But it covers the full range of tirzepatide dosing up to 15mg at most concentrations
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These pharmacologic distinctions account for the observed efficacy differences and potential complexity when switching between the two
