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When GLP-1 receptors are activated: The hypothalamus receives satiety signals, reducing hunger drive Gastric emptying is slowed, prolonging post-meal fullness Pancreatic beta cells increase insulin secretion in a glucose-dependent manner This is the same pathway targeted by semaglutide and liraglutide

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Basal glucose can be controlled, but the prandial problem persists- its the next target Diabetes Care

If response and tolerability look good, switch to prepay for the savings