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Qi L, Gao R, Chen Z, Lin D, Liu Z, Wang L, Lin L, Liu X, Liu X, Liu L (2022) Liraglutide reduces oxidative stress and improves energy metabolism in methylglyoxal-induced SH-SY5Y cells

As a result, GLP-1RAs should not be prescribed for treating BED

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Given that PKC and TRPM5 are downstream effectors of Gq signalling in beta cells, our next step involved determining whether the PKC inhibitor (calphostin C) and TRPM5 blocker (TPPO) suppress the triagonist-induced increase in GSIS

GLP-1 drugs such as Ozempic, Wegovy, and Zepbound have transformed obesity treatment, helping millions lose significant weight
