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By day 10, about half the drug remains

doi: 10.1016/j.molmet.2022.101638 87 GasbjergLSHelstedMMHartmannBSparre-UlrichAHVeedfaldSStensenSet al

In Canada, provincial variation and authorization processes fragment access

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Tirzepatide demonstrated approximately 5-fold lower affinity at the GLP-1 receptor compared to native GLP-1, and 20-fold lower potency in cellular signaling compared to semaglutide
