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Understanding rare and serious side effects of tirzepatide More serious side effects can occur with both Mounjaro and Zepbound, though these are far less likely

In contrast to common obesity, where cardiovascular risk reduction drives intervention, the main rationale for treatment in MC4R -deficient patients shifts toward alleviating mechanical complications (e.g., sleep apnea, osteoarthritis), preventing diabetes (hyperinsulinemia is common despite relative euglycemia), and improving quality of life [30]

Common Questions About GLP-1 Medications and Muscle Loss Do GLP-1 medications cause muscle loss

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Obesity 33 , 17251733 (2025)

But that lower baseline may mean your existing medications work more effectively, your flares are less severe, and your overall quality of life improves