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This is a cosmetic change, not a medical danger, but it understandably bothers many patients

However, they remain subject to side effects such as nausea, vomiting, and GI changes, which are dose- and individual-dependent

Given that glucose variability has been associated with endothelial dysfunction and oxidative stress, both of which contribute to the development and progression of CVD [23,24,25], improving glucose variabilitysomething that cannot be accurately assessed using HbA1c valuesmay represent a novel therapeutic target for managing T2DM

GLP-1 drugs may also cause other side effects, among them nausea, gastrointestinal issues and fatigue

Eat healthy proteins and fats

Thus, the decrease in leptin that accompanies calorific restriction contributes to the activation of the neuroendocrine starvation response