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Over the past two years, the competition between the companies has shifted away from injections and toward pill forms of the drugs, which offer a lower barrier for patients

Bioavailability: Even with SNAC technology, oral semaglutide has only 0.4-1% bioavailability compared to injectable semaglutide

There was also a reduction in IL-5, 13, and the number of Th2 cells in the lungs compared to semaglutide treatment, but with respect to IL-33, semaglutide was more powerful as its release is mediated particularly through the agonism of the GLP-1 receptor in which tirzepatide has less affinity

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Czym dual-agonista rni si od mono- i triple-agonisty