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American pharmaceutical major Eli Lilly has been running a multimedia obesity awareness campaign since last year, including ad films featuring well-known actors Boman Irani, Ratna Pathak and Supriya Pathak to raise awareness of obesity as a disease and encourage doctor consultations

Avoid strenuous activities, heavy lifting, and abdominal strain for 46 weeks

Per Ridha 2024 (PMID 38874170), the medial cheek fat compartment is among the most affected, producing the flattened cheek and deepened nasolabial fold appearance

JCI insight 5 (6), e133429

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At the same time, history offers numerous examples of treatments that appeared promising early on but later revealed safety concerns, unexpected adverse effects, or limited long-term benefit