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A meta-analysis of 21 clinical studies showed a weighted mean difference in body weight of 2.9 kg (95% confidence interval [CI] 3.6 to 2.2) with the maximum dose of each one of the GLP-1RAs [43]

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Much progress has been made toward effective pharmacological interventions involving single, dual, or triple agonists, taking advantage of glucagon-like peptide 1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor, and glucagon receptor agonists (4)