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A significant limitation of these reports, however, is that they did not specifically assess for sight-threatening complications from DR, which account for most of the long-term ocular morbidity associated with type 2 diabetes, they wrote

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Increased muscle mass may also enhance energy expenditure and redirect energy use toward muscle rather than fat storage.[22] In humans, elevated MSTN levels have been associated with obesity.[27] In mice, MSTN inhibition reduces white fat accumulation, improves lipid metabolism in diabetic models, and promotes browning of white fat.[28] As low muscle mass is a risk factor for insulin resistance and obesity,[29] increasing muscle via MSTN blockade may enhance insulin sensitivity, partly through irisin-driven crosstalk between muscle and fat.[30] Irisin is an exercise-induced adipomyokine, generated by cleavage of the transmembrane protein fibronectin type III domain-containing protein 5 predominantly in skeletal muscle and, to a lesser extent, in adipose tissue

In a separate shaker cup or small bowl, mix the whey protein powder with the remaining 1/4 cup of cold water until perfectly smooth

& Polyzos, S
