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That said, more effective on average doesnt automatically mean right for you. Semaglutide has a longer real-world track record, a wider set of approved uses, and is frequently easier to get covered all of which can matter more than a few percentage points

Semaglutide does not undergo significant liver metabolism and does not stress hepatic function

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GLP-1 and dopamine crosstalk was shown in rat WAT explants, since dopamine upregulated GLP-1-induced AMPK activity in mesenteric WAT in the presence of the D2R and D3R inhibitor Domperidone