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& Study 1821 Investigators 2016 A Phase 2, randomized, dose-finding study of the novel once-weekly human GLP-1 analog, semaglutide, compared with placebo and open-label liraglutide in patients with type 2 diabetes

A 5 to 10 beat per minute increase that a 35-year-old barely notices might cause fatigue, exercise intolerance, or shortness of breath in a 65-year-old

The first week on semaglutide often produces subtle effects, primarily mild appetite reduction and perhaps slight nausea that comes and goes

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