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In addition, glucagon may contribute, at least partly, to the development of diabetic cardiomyopathy, as antagonism of the GCGR reduced its incidence in a mouse model of diabetes over several months (Sharma et al

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Clinical pharmacology biopharmaceutics review: liraglutide

All of these drugs control obesity by making people feel less hungry, but Tamara Milder, an endocrinologist with UNSW, told me they also directly improve cardiovascular and kidney health on top of the benefits from weight reduction

Hence, GLP-1RAs can be utilized as an adjunct alongside metformin as a first-line treatment for type 2 DM or, in specific cases, as a preferred therapeutic agent when additional benefits for cardiovascular or renal protection are required [84]

[DOI] [PMC free article] [PubMed] [Google Scholar] 87.Yang Y, et al