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Unclear Long-Term Outcomes: While we understand the impact of the drug taken at therapeutic doses, we do not know what impact microdosing tirzepatide might have on weight trajectories, cardiometabolic health, adherence or psychological outcomes

If GI side effects persist beyond the adjustment period or are severe enough to significantly impact quality of life, dose adjustment may be warranted

When used under proper medical supervision these drugs can help patients manage their weight with dignity and support

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