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Sustained GIPR agonism shifts post-prandial glucose toward glycerol production and promotes lipolysis during fasting, enhancing lipid clearance and mobilization beyond what GLP-1R agonism achieves alone 14

The glucose-dependent effects theory highlights that both hormones work in glucose-dependent ways but with different patterns

This is biology doing exactly what it evolved to do

At 7.2 mg, semaglutide produces 18.7% vs

Side Effects: Both drugs share similar side effects, including nausea, vomiting, and gastrointestinal discomfort, but these are generally mild and decrease over time as the body adjusts to the medication

Bass says, but this varies