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While no published data specifically measures the combined risk, the theoretical concern is straightforward: two independent risk factors for the same serious condition are unlikely to be safer together

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If dry mouth is genuinely intolerable and significantly impacting your quality of life, conversion to a different GLP-1 agent is worth discussing with your provider

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Clinicians should take a thorough cardiovascular history and record a baseline heart rate before initiating treatment, and reassess regularly throughout the course of therapy