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These effects are thought to result from combined modulation of hypothalamic appetite-regulating pathways and mesolimbic reward circuits, as shown in studies using pharmacological antagonists and viral knockdown techniques targeting GLP-1Rs

This cascade also precipitates renal cell proliferation and hypertrophy, increased extracellular matrix synthesis, and subsequent macrophage activation and inflammation [5,7]

2021;13(9):e18080

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GLP-1 can promote intracellular cholesterol outflow, reduce intracellular cholesterol content, and maintain intracellular cholesterol homeostasis through the ABCA1 pathway

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