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Because GLP-1 drugs work by binding to these receptors, the bigger reduction in blood sugar may be explained by greater binding activity spurring more insulin production

Akomaning, E

The semaglutide and tirzepatide trials changed that expectation: Semaglutide 2.4 mg once weekly produced average weight loss around 15% at ~68 weeks in adults without diabetes, with a substantial fraction of participants losing 1520% of baseline weight

Endocr Rev 2019;40:116 [DOI] [PMC free article] [PubMed] [Google Scholar] 7

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