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To summarize the structural optimization of DEL7, we found that elongation of the alkyl chain of the R1 group with incorporation of nitrogen-containing groups allows extension beyond the S3 site, reaching towards the other protomer of the native homodimer of 3CL protease, engaging additional interactions with the active site and the interacting protomer, and substantially improving potency for inhibiting the purified protease (Supplementary Fig

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Glutamine, the most abundant amino acid in the body, is found in most protein sources but particularly high concentrations exist in beef, pork, poultry, fish, eggs, dairy products, cabbage, and beans

[DOI] [PubMed] [Google Scholar] 205.Ikeno M, Hibi H, Kinoshita K, Hattori H, Ueda M