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The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

MedRxiv The Preprint Server for Health Services

FDA Approved AOD 9604 has FDA GRAS status, meaning it's Generally Recognized As Safe for use

It is a small-molecule NNMT inhibitor

Its considered the safest choice for both adults and children, regardless of age, gender, ethnicity, or BMI

She writes here on the treatments CoLaz delivers across its seven UK clinics