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But after burning through some $50 million developing the drug, Metabolic Pharmaceuticals Pty Ltd, which owns the patent, has continued to spruik its so-called body-enhancing benefits

Oral administration results in rapid degradation by gastric acid and hepatic first-pass metabolism, rendering the compounds inactive before reaching systemic circulation

A dose of 1,000 mcg is often used, mainly for severe cases or initial treatment

[DOI] [PubMed] [Google Scholar] 229.Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM
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