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For this reason, several novel NBDHEX analogues, with improved selectivity for GSTP1-1, have been synthesized and characterized to obtain new therapeutic opportunities for the treatment of drug resistant tumors including human melanoma 100,101

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51 Thus, further pharmaceutical development is essential to improve the water solubility and bioavailability of panduratin A for the use of fingerroot extract as a phytopharmaceutical product

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